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Synthesis of [ 14 C]‐labelled dihydropyridine calcium channel entry blockers: Nicardipine‐[4‐ 14 C] and RS‐93522‐[4‐ 14 C]
Author(s) -
Parnes Howard,
Huang Glenn T.,
Shelton Emma J.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250606
Subject(s) - chemistry , nicardipine , dihydropyridine , yield (engineering) , chemical synthesis , calcium channel , ring (chemistry) , calcium , aryl , stereochemistry , radiochemistry , medicinal chemistry , organic chemistry , in vitro , biochemistry , materials science , alkyl , metallurgy
The Hantzsch synthesis has been applied to the general preparation of 4‐aryl‐dihydropyridines labelled in the metabolically stable 4‐position of the dihydropyridine ring. The synthesis is based on the preparation of a key common intermediate, m‐nitrobenzaldehyde‐[formyl‐ 14 C], in high yield from Ba 14 CO 3 .