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The comparative synthesis of 18 F‐fluorophenylalanines by electrophilic substitution with 18 F‐F 2 and 18 F‐AcOF
Author(s) -
Murakami M.,
Takahashi K.,
Kondo Y.,
Mizusawa S.,
Nakamichi H.,
Sasaki H.,
Hagami E.,
Iida H.,
Kanno I.,
Miura S.,
Uemura K.
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250511
Subject(s) - chemistry , yield (engineering) , reagent , radiochemistry , stereochemistry , physics , thermodynamics
Abstract Fluorination with 18 F‐F 2 and 18 F‐AcOF were compared for the synthesis of 18 F‐fluorophenylalanines. L‐phenylalanine in CF 3 COOH trapped 18 F‐AcOF more effectively than 18 F‐F 2 . The main product was ortho‐ 18 F‐fluorophenylalanine when 18 F‐AcOF was used as a reagent. Lower radiochemical yield of 18 F‐fluorophenylalanines and significant formation of by‐product were observed in the case of 18 F‐F 2 .