Premium
Synthesis of 14 C‐labeled stepholidine
Author(s) -
Liu Yang,
Xin Zhang
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250510
Subject(s) - chemistry , yield (engineering) , methylation , condensation , medicinal chemistry , organic chemistry , biochemistry , materials science , physics , metallurgy , gene , thermodynamics
(8‐ 14 C)Stepholidine was synthesized by Mannich condensation of 7‐benzyloxy‐1‐(4‐benzyloxy‐3‐hydroxybenzyl)‐6‐methoxy‐1,2,3,4‐ tetrahydroisoquinoline ( 2 ) with ( 14 C)formalehyde at pH 6.4 followed by methylation and debenzylation in 32% radiochemical yield.