Premium
The synthesis of deuterium labeled T‐2 toxin
Author(s) -
Michaud Dennis P.,
Karger B. L.,
Vouros Paul
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250314
Subject(s) - chemistry , acetic anhydride , yield (engineering) , toxin , hydrolysis , mycotoxin , deuterium , tritium , chemical synthesis , organic chemistry , chromatography , stereochemistry , radiochemistry , combinatorial chemistry , in vitro , biochemistry , catalysis , materials science , physics , food science , quantum mechanics , nuclear physics , metallurgy
We report the synthesis of isotopically pure trideuteriated T‐2 toxin, a useful internal standard for mycotoxin analysis. Peracetylation of HT‐2 toxin with hexadeuteriated acetic anhydride, followed by selective hydrolysis of the C‐3 acetate afforded the desired compound in good yield.