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Synthesis of [ 14 C]hippuryl‐L‐histidyl‐L‐leucine
Author(s) -
Prior K J,
Wiltshire H R,
Smith G M
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250303
Subject(s) - chemistry , yield (engineering) , barium , leucine , substrate (aquarium) , specific activity , enzyme , radiochemistry , stereochemistry , nuclear chemistry , organic chemistry , biochemistry , amino acid , metallurgy , materials science , oceanography , geology
This paper describes the synthesis of [ 14 C]hippuryl‐L‐histidyl‐L‐leucine (hip‐his‐leu) from barium [ 14 C]carbonate. An overall radiochemical yield of 36% was obtained giving pure material with a specific activity of 17 mCi/mmol and a suitable substrate for the assay of angiotensin converting enzyme (ACE).