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Synthesis of tritium labeled 7α‐methoxycarbonyl‐15β,16β‐methylene‐3‐oxo‐17α‐pregn‐4‐ene‐21, 17‐carbolactone, [ 3 H]SH‐D515, a highly selective tracer for the mineralocorticoid receptor
Author(s) -
Nickisch Klaus,
Laurent Henry,
Schulze PaulEberhard,
Grill HansJörg,
Pollow Kunhard
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250208
Subject(s) - chemistry , ene reaction , tritium , aldosterone , mineralocorticoid receptor , methylene , antagonist , receptor , chemical synthesis , stereochemistry , steroid , radiochemistry , medicinal chemistry , endocrinology , biochemistry , in vitro , hormone , medicine , physics , nuclear physics
The synthesis of 7α‐methoxycarbonyl‐15β,16β‐methylene‐3‐oxo‐17α‐pregn‐4‐ene‐21,17‐carbolactone ( 5 , SH‐D515, ZK 91587), a potent aldosterone antagonist exhibiting a strong and very selective binding to the mineralocorticoid receptor and the tritiated analog 6 is reported.