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Synthesis of D/L‐ and L‐SE‐[methyl‐ 11 C]selenomethionine
Author(s) -
Någren Kjell,
Långström Bengt
Publication year - 1988
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580250204
Subject(s) - chemistry , methyl iodide , selenium , yield (engineering) , liquid ammonia , selenide , alkylation , radiochemistry , sodium iodide , ammonia , enantiomer , iodine , nuclear chemistry , medicinal chemistry , organic chemistry , catalysis , materials science , metallurgy
The syntheses of D/L‐ and L‐Se‐[methyl‐ 11 C]selenomethionine are reported. The Se‐benzyl selenohomocysteines were deprotected in sodium/liquid ammonia and the selenide anions generated in situ were alkylated with [ 11 C]methyl iodide to give, after purification by LC, the products in 80 to 85 % radiochemical yield, with a radiochemical purity higher than 99 % within 30 min and with a specific radioactivity of 20 to 200 mCi/μmol. The enantiomeric purity of the L‐compound, determined by LC, was higher than 99 %.