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S‐Adenosyl‐L‐(1‐ 14 C)‐homocysteine
Author(s) -
Thomas H. Jeanette,
Montgomery John A.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580241215
Subject(s) - chemistry , homocysteine , salt (chemistry) , sodium , liquid ammonia , ammonia , plasma homocysteine , sodium salt , medicinal chemistry , nuclear chemistry , inorganic chemistry , organic chemistry , biochemistry
S‐Adenosyl‐L‐(1‐ 14 C)‐homocysteine ( 3 ) was prepared from commercially available L‐(1‐ 14 C)‐methionine ( 1 ) by conversion first to S‐benzyl‐L‐(1‐ 14 C)‐homocysteine ( 2 ), which upon treatment with sodium in liquid ammonia gave the disodium salt of L‐(1‐ 14 C)‐homocysteine. Reaction of this sodium salt with 5′‐O‐tosyladenosine gave 3 .