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Synthesis of dopexamine hydrochloride labelled with tritium, deuterium and carbon‐14
Author(s) -
Wilkinson D J,
Lockley W J S
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580241206
Subject(s) - chemistry , tritium , ethylamine , deuterium , hydrochloride , halogenation , carbon 14 , chemical synthesis , catalytic hydrogenation , radiochemistry , derivative (finance) , catalysis , organic chemistry , medicinal chemistry , physics , quantum mechanics , nuclear physics , financial economics , economics , biochemistry , in vitro
Dopexamine hydrochloride labelled with carbon‐14 has been prepared by a mixed anhydride reaction between 6‐[[2‐(3,4‐dimethoxyphenyl)ethyl]amino]‐6‐oxohexanoic acid, ethyl carbonochloridate and 2‐phenyl‐[1‐ 14 C]ethylamine. Deuterium isotopomers have been prepared by exchange, reduction of an unsaturated precursor, and by reductive dehalogenation of a chloro‐derivative. Tritium‐labelled compound was obtained by acid‐catalyzed tritium exchange.