Premium
Synthesis of tritium and deuterium labeled 8‐N‐ n ‐butyl‐N‐methylamino‐8‐(3‐hydroxyphenyl)‐1,4‐dioxaspiro[4,5]decane hydrochloride
Author(s) -
Hsi Richard S. P.,
Kurtz Richard R.,
Moon Malcolm W.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580241115
Subject(s) - chemistry , tritium , deuterium , hydrochloride , decane , radiochemistry , derivative (finance) , tritium illumination , organic chemistry , medicinal chemistry , physics , quantum mechanics , nuclear physics , financial economics , economics
The title compound, a 4‐amino‐4‐arylcyclohexanone derivative with central analgesic activity, was labeled with tritium at the C‐7 and C‐9 positions. Deuterium labeled intermediates were used as models for developing isotope exchange and synthetic procedures. Deuterium and tritium labeled title compounds were obtained in five steps with overall yields of 18‐22% from 1,4‐dioxaspiro[4,5]‐decan‐8‐one and 3‐bromophenol.