Synthesis of 1‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]‐3‐(3‐pyridazinon‐2‐YL)‐[3‐ 14 C]propane hydrochloride (gyki‐12743), a new antihypertensive agent | Zendy

BirkásFaigl E. | Zendy; Zólyomi G. | Zendy; Makk N. | Zendy; Kasztreiner E. | Zendy

Premium

Synthesis of 1‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]‐3‐(3‐pyridazinon‐2‐YL)‐[3‐ 14 C]propane hydrochloride (gyki‐12743), a new antihypertensive agent

Author(s) -

BirkásFaigl E.,

Zólyomi G.,

Makk N.,

Kasztreiner E.

Publication year - 1987

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2580241109

Subject(s) - chemistry , potassium cyanide , yield (engineering) , propane , hydrochloride , cyanide , carbon 14 , potassium , medicinal chemistry , cyanide ion , combinatorial chemistry , nuclear chemistry , radiochemistry , stereochemistry , organic chemistry , materials science , metallurgy , physics , quantum mechanics

A new antihypertensive agent, GYKI‐12743, has been labelled with carbon‐14 via a six‐step synthesis. The label was introduced by chain elongation of an appropriate precursor using potassium [ 14 C]cyanide as radioactive starting material. A satisfactory overall yield, 44.7 %, relative to KCN was achieved.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research