Preparation of tritium‐labeled diosgenin, esmilagenin and tigogenin | Zendy

Rabinowitz Joseph L. | Zendy; Zagoya Juan C. Diaz | Zendy

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Preparation of tritium‐labeled diosgenin, esmilagenin and tigogenin

Author(s) -

Rabinowitz Joseph L.,

Zagoya Juan C. Diaz

Publication year - 1987

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2580241104

Subject(s) - diosgenin , chemistry , sapogenin , silica gel , chromatography , gas chromatography , column chromatography , tritium illumination , tritium , ethyl acetate , organic chemistry , medicine , physics , alternative medicine , pathology , nuclear physics

The synthesis of 3 H ‐diosgenin, 3 H ‐esmilagenin and 3 H ‐tigogenin (three potential hypocholesterolemic agents) was accomplished by low pressure hydrogenation of commercial (Sigma D 1634) diosgenin with 3 H ‐gas. The mixture of 3 H materials obtained was separated by silica gel G‐60 column chromatography by use of a benzene: ethyl acetate (8:2 v/v) solution. Purification of each sapogenin was by TLC chromatography.

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