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Synthesis of high specific activity carbon‐14 labeled PD‐113,926 and CI‐930, potential new cardiotonic agents
Author(s) -
Hays Sheryl J.,
Hicks James L.,
Huang C. C.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580241006
Subject(s) - chemistry , wittig reaction , olefin fiber , aqueous solution , carbon fibers , medicinal chemistry , nuclear chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , composite number , materials science , composite material
Double‐labeled PD‐113,926 and CI‐930 were synthesized from [ 14 C]MeI and [ 14 C]BaCO 3 respectively in high specific activity (>90 mCi/mmol). The synthesis of CI‐930 employed the intermediate 2‐butenenitrile‐3,4‐ 14 C 2 which was synthesized by a phase transfer Wittig procedure. This Wittig procedure is fast, produces moderate to good yields of olefin and accommodates the use of aqueous solutions of aldehydes.