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Modified and improved method for synthesis of p‐halogenated‐N‐isopropylamphetamine leading to synthesis of “no carrier added” I‐131 iodoamphetamine
Author(s) -
Najafi A.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580241004
Subject(s) - chemistry , isopropyl , sodium iodide , high performance liquid chromatography , iodine 123 , chemical synthesis , chromatography , iodide , sodium , radiosynthesis , combinatorial chemistry , radiochemistry , organic chemistry , biochemistry , nuclear medicine , in vitro , positron emission tomography , medicine
I‐123 labeled N‐isopropyl‐p‐iodoamphetamine (IMP) has been shown to be an important and useful radiopharmaceutical for measurement of cerebral blood flow ( 1–4 ). Since substituted amphetamines have a strong pharmacological activity, the synthesis of “No Carrier Added” (NCA) labeled IMP would be desirable ( 5 ). In this paper we would like to report a modified and improved method for the synthesis of para‐halogenated‐N‐isopropylamphetamine and the preparation of NCA I‐131 IMP. This procedure involves a labeling reaction using I‐131 sodium iodide and para‐bromo‐N‐isopropyl amphetamine (BrMP) followed by HPLC separation of I‐131 IMP and BrMP using reverse phase chromatography.