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An improved synthesis of [ 15 N] 16‐doxyl stearic acid
Author(s) -
Joseph Joy,
Lai ChingSan
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580241003
Subject(s) - chemistry , yield (engineering) , stearic acid , stearate , mole , volume (thermodynamics) , organic chemistry , nuclear chemistry , medicinal chemistry , materials science , physics , quantum mechanics , metallurgy
An improved method for the synthesis of [ 15 N] 16‐Doxyl stearate, a fatty‐acid spin label, is reported. The method requires only one mole of [ 15 N] 2‐amino‐2‐methyl propanol per mole of methyl keto stearate with an overall yield of about 50%. In contrast, the previous method produced only 1‐3% yield. The great improvement in yield was achieved mainly through the reduction of reaction volume which increases the reaction rate by the law of mass action.