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The Synthesis of 8‐β‐[(Methylsulfinyl‐[ 18 O])‐methyl]‐6‐propylergoline
Author(s) -
Wheeler William J.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240914
Subject(s) - pergolide , chemistry , sulfoxide , acetic acid , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , agonist , receptor , dopamine agonist
The synthesis of 18 O‐labeled 8‐β‐[(methylsulfinyl)‐methyl]‐6‐propyl‐ergoline (pergolide‐[ 18 O]‐sulfoxide) of undetermined stereochemistry by the reaction of 8‐β‐(methylthiomethyl)‐6‐propyl‐ergoline (pergolide) with bis ‐(4‐methoxyphenyl)‐selen‐[ 18 O]‐oxide in acetic acid is described. Although the yields were low and the incorporation of 18 O was not high, this procedure represents a convenient method for the preparation of 18 O‐labeled sulfoxides of pergolide and other sulfides present in compounds for which the usual methods are inappropriate.