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Synthesis of 1‐ 14 C‐(1S, 4S)‐N‐methyl‐4‐(3,4‐dichlophenyl)‐1,2,3,4‐tetrahydro‐1‐naphthalenamine L‐mandelate (1‐ 14 C‐sertraline mandelate)
Author(s) -
Welch Willard M.,
Viveiros Dawn M.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240814
Subject(s) - chemistry , yield (engineering) , sertraline , nuclear chemistry , medicinal chemistry , antidepressant , stereochemistry , radiochemistry , materials science , neuroscience , biology , hippocampus , metallurgy
The preparation of the title compound, a selective 5‐HT uptake blocker with potential antidepressant properties in man, is described. The labelled material with a specific activity of 0.7 mCi/mmol, was synthesized in 7 steps from K 14 CN in 6.5% radiochemical yield.