Synthesis of 7‐(4′‐fluoro‐3,3′,5‐trimethyl[1,1′‐biphenyl]‐2‐YL)‐3‐hydroxy‐5‐OXO‐5‐ 13 C‐heptanoic acid and trans‐6‐[2‐(4′‐fluoro −3,3′,5‐trimethyl[1,1′‐biphenyl]‐2‐YL)ethyl]‐3,4,5,6‐tetrahydro‐6‐ 13 C‐4‐hydroxy‐2H‐pyran‐2‐one | Zendy

Stokker Gerald E. | Zendy

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Synthesis of 7‐(4′‐fluoro‐3,3′,5‐trimethyl[1,1′‐biphenyl]‐2‐YL)‐3‐hydroxy‐5‐OXO‐5‐ 13 C‐heptanoic acid and trans‐6‐[2‐(4′‐fluoro −3,3′,5‐trimethyl[1,1′‐biphenyl]‐2‐YL)ethyl]‐3,4,5,6‐tetrahydro‐6‐ 13 C‐4‐hydroxy‐2H‐pyran‐2‐one

Author(s) -

Stokker Gerald E.

Publication year - 1987

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2580240714

Subject(s) - chemistry , biphenyl , reductase , stereochemistry , hmg coa reductase , enzyme , biochemistry , organic chemistry

The title compounds are potent HMG‐CoA reductase inhibitors. A 13 C‐label was introduced into these compounds to permit probing of their interaction with HMG‐CoA reductase by 13 C NMR techniques in the presence and absence of added NADPH.

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