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Synthesis of 7‐(4′‐fluoro‐3,3′,5‐trimethyl[1,1′‐biphenyl]‐2‐YL)‐3‐hydroxy‐5‐OXO‐5‐ 13 C‐heptanoic acid and trans‐6‐[2‐(4′‐fluoro −3,3′,5‐trimethyl[1,1′‐biphenyl]‐2‐YL)ethyl]‐3,4,5,6‐tetrahydro‐6‐ 13 C‐4‐hydroxy‐2H‐pyran‐2‐one
Author(s) -
Stokker Gerald E.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240714
Subject(s) - chemistry , biphenyl , reductase , stereochemistry , hmg coa reductase , enzyme , biochemistry , organic chemistry
The title compounds are potent HMG‐CoA reductase inhibitors. A 13 C‐label was introduced into these compounds to permit probing of their interaction with HMG‐CoA reductase by 13 C NMR techniques in the presence and absence of added NADPH.