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The synthesis of high radiochemical purity of 2‐[ 18 F]‐fluoro‐2‐deoxy‐D‐glucose without the use of preparative hplc
Author(s) -
Ginos James Z.,
French Robert,
Reamer Robert
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240711
Subject(s) - chemistry , fluoride , yield (engineering) , high performance liquid chromatography , radiochemistry , chromatography , nuclear chemistry , inorganic chemistry , materials science , metallurgy
A process is described for preparing routinely sterile and pyrogenfree, multimillicurie amounts of 2‐[ 18 F]‐fluoro‐2‐deoxy‐D‐glucose ( 18 F‐2FDG) with and without carrier‐added fluoride and with a radiochemical purity of greater than 98% without the use of preparative HPLC. For 13 consecutive runs, the radiochemical yield with carrier‐added fluoride was 35.5 ± 2.2%. The [ 18 F]fluoride used was produced by the reaction 16 0( 3 He, p) 18 F or by the reaction 18 0 (p,n) 18 F. Analytical HPLC, 1 H and 19 F NMR spectral analysis were used to establish the identity and purity of 18 F‐2FDG.