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Synthesis of deuterated and tritiated gossypol
Author(s) -
Stipanovic Robert D.,
Williams Howard J.,
Muehleisen David P.,
Plapp F. W.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240616
Subject(s) - chemistry , tritiated water , gossypol , deuterium , trifluoroacetic acid , tetrahydrofuran , hydrogen–deuterium exchange , tritium , catalysis , radiochemistry , organic chemistry , hydrogen , biochemistry , nuclear physics , physics , solvent
We report here the synthesis of deuterated and tritiated gossypol by exchange with labelleled water using trifluoroacetic acid as the catalyst. In the case of D 2 O in tetrahydrofuran, the exchange is complete in 45 minutes at 75°C as determined by a 1 H‐NMR spectrum.