Synthesis of 2‐amino‐1,5‐dihydro‐1‐(methyl‐ 13 C)‐4H‐imidazol‐4‐one‐5‐ 13 C (creatinine‐ 13 C 2 ) | Zendy

Cohen A. | Zendy; Hertz H. H. | Zendy; Schaffer R. | Zendy; Welch M. M. | Zendy; White E. | Zendy

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Synthesis of 2‐amino‐1,5‐dihydro‐1‐(methyl‐ 13 C)‐4H‐imidazol‐4‐one‐5‐ 13 C (creatinine‐ 13 C 2 )

Author(s) -

Cohen A.,

Hertz H. H.,

Schaffer R.,

Welch M. M.,

White E.

Publication year - 1987

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2580240514

Subject(s) - chemistry , sarcosine , cyanamide , yield (engineering) , medicinal chemistry , sublimation (psychology) , creatine , organic chemistry , stereochemistry , glycine , nuclear chemistry , amino acid , psychology , biochemistry , materials science , metallurgy , psychotherapist

2‐Amino‐1,5‐dihydro‐1‐(methyl‐ 13 c)‐4h‐imidazol‐4‐one‐5‐ 13 c (creatinine‐ 13 C 2 ) ( 8 ) is synthesized as follows. Glycine‐2‐ 13 c ( 1 ) is tosylated; the product ( 2 ) is treated with iodomethane‐ 13 C; and the resultant doubly‐labeled product ( 3 ) is detosylated to yield sarcosine‐ 13 C 2 ( 4 ). Creatine‐ 13 C 2 ( 7 ) is obtained by treating 4 with 2‐methylisothiourea monohydriodide ( 5 ) or cyanamide ( 6 ). Dehydration of 7 under vacuum sublimation conditions gives 8 .

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