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Synthesis of cis‐diamino‐[1,1‐[1‐ 14 C]cyclobutanedicarbonyloxy (2)‐0,0] platinum II
Author(s) -
Haynes U. U.,
Swigor J. J.,
Pittman K. K.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240509
Subject(s) - chemistry , potassium hydroxide , diethyl malonate , ammonium hydroxide , platinum , saponification , salt (chemistry) , sodium hydroxide , potassium nitrate , potassium , methyl iodide , medicinal chemistry , nuclear chemistry , ethyl iodide , malonate , iodide , silver nitrate , hydroxide , iodine , inorganic chemistry , organic chemistry , catalysis
The synthesis of the title compound (4) is described. [2‐ 14 C]Diethyl malonate was treated simultaneously with a freshly prepared solution of sodium ethoxide and 1,3‐dibromopropane to give 1 1‐[1‐ 14 C]cyclobutanedicarboxylic acid diethyl ester (1). Treatment with potassium hydroxide saponified the ester leaving the dipotassium salt (2). Conversion of potassium tetrachloroplatinate II with potassium iodide followed by ammonium hydroxide resulted in cis‐diamino‐diiodoplatinum II 1 (3). Reaction of (3) with 1,1‐[1‐ 14 C]cyclobutanedicarboxylic acid dipotassium salt in the pressence of silver nitrate resulted in the title compound (4).