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Synthesis of tritium labelled ropivacaine — A new potential local anesthetic
Author(s) -
Gawell Lars
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240507
Subject(s) - chemistry , tritium , ropivacaine , tritium illumination , enantiomer , anesthetic , derivative (finance) , radiochemistry , stereochemistry , pharmacology , anesthesia , nuclear physics , medicine , physics , financial economics , economics
A potential local anesthetic, ropivacaine, is synthesized labeled with tritium. The label is introduced by reduction of a racemic tetrahydropyridine derivative with tritium gas. Resolution into the labeled enantiomers is accomplished by preferential crystallization with added carrier. The location of the tritium label is verified by 3 H NMR.