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Synthesis of deuterium labelled triazolobenzodiazepines
Author(s) -
Koves G. J.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240412
Subject(s) - chemistry , deuterium , acylation , triazolam , organic chemistry , benzodiazepine , biochemistry , catalysis , physics , quantum mechanics , receptor
Alprazolam and Triazolam ‐ anxyolitic and hypnotic agents ‐ were labelled with deuterium. First synthesis: through CD 3 COOD acylation of the appropriate Hydrazones, followed by thermal cyclization. Second synthesis: deuterium exchange through acid catalized carbocation intermediates in a CD 3 COOD/D 2 SO 4 mixture. The products were used as internal standards for GC/MS/SIM quantitative analysis in forensic case work.