Premium
Synthèse de la diméthoxy‐6,7 ( para ‐chlorobenzyl)‐4 isoquinoléine, deutériée en position 3 ou marquée au 14 C sur le méthylène benzylique
Author(s) -
Bouvier P.,
Mourlevat F.,
Pichat L.,
Servin A.,
Viel C.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240411
Subject(s) - chemistry , isoquinoline , medicinal chemistry , methylene , condensation reaction , stereochemistry , organic chemistry , catalysis
6,7‐dimethoxy‐4 ( para chlorobenzyl) (D‐3) isoquinoline : 6 and 6,7‐dimethoxy‐4 [ para chlorobenzyl (methylene 14 C)] isoquinoline: 11 were prepared respectively by the condensation of α‐deuterio‐veratrylaminoacetaldehyde diethylacetal : 4 with para chlorobenzaldehyde and the reaction of para chlorobenzaldehyde (carbonyl 14 C) : 9 with veratrylaminoacetaldehyde diethylacetal.