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Synthesis of tritium labeled O‐ethyl‐ D ‐tyrosine and phenylalanine
Author(s) -
Landvatter Scott W.,
Heys J. Richard,
Senderoff Stephen G.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240406
Subject(s) - tritium , chemistry , phenylalanine , tyrosine , tritium illumination , derivative (finance) , radiochemistry , specific activity , amino acid , nuclear chemistry , organic chemistry , enzyme , biochemistry , physics , nuclear physics , financial economics , economics
Two amino acids, t ‐BOC‐O‐ethyl‐ D ‐tyrosine and t ‐BOC‐phenylalanine, have been synthesized in tritium labeled form via exchange with tritium gas over catalyst on an unlabeled precursor and dehydrohalogenation on an iodinated precursor respectively. The tyrosine derivative has been obtained in specific activities of 4 ‐ 7 Ci/mmol; tritium NMR indicates that at least 80% of the tritium resides in the benzylic position of the molecule. The phenylalanine has been synthesized with a specific activity of greater than 35 Ci/mmol. Tritium NMR confirms specific tritium/iodine replacement in the position.