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Synthesis of deuterium labeled 1,3‐dimethyluric acid
Author(s) -
Mamada Kumiko,
Furuta Takashi,
Kasuya Yasuji
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240403
Subject(s) - chemistry , deuterium , chemical synthesis , methylation , bicyclic molecule , isotope , medicinal chemistry , radiochemistry , organic chemistry , stereochemistry , biochemistry , in vitro , physics , quantum mechanics , gene
A synthetic procedure for 1,3‐di(trideuteromethyl)uric acid is described. Deuterium labeling of the N‐1 and N‐3 positions was achieved by methylation of 4‐amino‐5‐carbethoxyuracil with di(trideuteromethyl)‐sulfate followed by cyclization of the dimethylated intermediate by heating. The synthesis resulted in a product with 99.4% d 6 isotopic purity, which is selectively deuterated in the methyl groups at the N‐1 and N‐3 positions and chemically pure.