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Synthesis of U‐ 14 C‐labelled 5‐hydroxymethyl‐2‐furaldehyde
Author(s) -
Germond J. J.,
Arnaud M. M.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240316
Subject(s) - chemistry , hydroxymethyl , yield (engineering) , ketone , dehydration , fructose , ion exchange resin , high performance liquid chromatography , chromatography , nuclear chemistry , radiochemistry , organic chemistry , biochemistry , materials science , metallurgy
Uniformally 14 C‐labelled 5‐hydroxymethyl‐2‐furaldehyde was synthesized by dehydration of D‐[U‐ 14 C]fructose on an H + ion exchange resin and a water isobutylmethyl ketone biphasic liquid reaction medium. The optimal reaction time was 45min, and after HPLC purification the radiochemical yield was 50%. The whole process took 2 hours.