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Synthesis of 11 C‐pindolol
Author(s) -
Prenant C.,
Sastre J.,
Crouzel C.,
Syrota A.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240212
Subject(s) - chemistry , pindolol , sodium cyanoborohydride , isopropyl , specific activity , imine , propylamine , medicinal chemistry , radiochemistry , nuclear chemistry , organic chemistry , biochemistry , amine gas treating , catalysis , receptor , enzyme
A method is described by which 100 mCi of pindolol may be obtained from about 1.5 Ci 11 CO 2 in 30 minutes. The product is chromatographically pure, sterile and apyrogenic with a specific activity between 600 and 1000 mCi/μmole at the time of use. The synthesis involves the preparation of 11 C‐acetone followed by fixation of the isopropyl group on the precursor : 2 hydroxy‐3 (4‐indolyoxy) propylamine by formation of an imine, the reduction of the latter by sodium cyanoborohydride.