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Synthesis of 13 C‐labeled polychlorinated biphenyls
Author(s) -
Roth Robert W.,
Heys J. Richard,
Saugier Joseph H.,
Chien David H. T.,
Rotert Gary A.,
Erickson Mitchell D.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240208
Subject(s) - biphenyl , polychlorinated biphenyl , chemistry , benzene , mass spectrum , isotope , mass spectrometry , carbon 13 , chromatography , environmental chemistry , organic chemistry , physics , quantum mechanics
Methods are described for the synthesis of 4‐chloro(1prime;,2prime;,3prime;,4prime;,5prime;,6′‐ 13 C 6 )biphenyl; 3,3′,4,4′‐tetrachloro( 13 C 12 )biphenyl; and 2,2′,3,3′,5,5′,6,6′‐octachloro( 13 C 12 )biphenyl; decachloro( 13 C 12 )biphenyl from ( 13 C 6 )benzene of ≧ 99 atom % isotopic purity, on scales of 100 mg to 1 g. The gas chromatographic retention time of each 13 C‐polychlorinated biphenyl (PCB) matched that of the corresponding unlabeled commercial reference standard, and the mass spectrum of each compound was consistent with an isotopic purity of ≧ 99 atom % 13 C. These compounds are useful as recovery surrogates and internal standards in the determination of PCBs in a variety of complex matrices.