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The preparation of regiospecific tritiated and deuterated dibenzacridines by catalytic exchange and [14‐ 14 C]dibenz‐[a,j]acridine
Author(s) -
Rosario Christopher A.,
Duke Colin C.,
Gill Jennifer H.,
Dawson Michael,
Holder Gerald M.,
Ghazy Tahany,
Long Mervyn A.
Publication year - 1987
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580240104
Subject(s) - chemistry , acridine , tritium , catalysis , deuterium , paraformaldehyde , tritium illumination , radiochemistry , labelling , cyclopentanes , acridine derivatives , tritiated water , hydrogen–deuterium exchange , medicinal chemistry , organic chemistry , stereochemistry , hydrogen , biochemistry , physics , quantum mechanics , nuclear physics
Abstract A practical synthesis of [14‐ 3 H]dibenz[a,j]acridine and [7‐ 3 H]dibenz[a,h]acridine is reported from the parent hydrocarbon by catalytic exchange with tritium gas in the presence of palladium on calcium carbonate. Analogous regiospecific labelling with deuterium was also affected. In addition [14‐ 14 C]dibenz[a,j]acridine was prepared from [ 14 C]paraformaldehyde.