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Synthesis of NO‐carrier added 11 C‐labelled [methyl]choline analogs
Author(s) -
Diksic Mirko,
Jolly Dean
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230911
Subject(s) - chemistry , yield (engineering) , choline , acetonitrile , solvent , methanol , base (topology) , carbon 14 , radiosynthesis , radiochemistry , nuclear chemistry , organic chemistry , in vivo , biochemistry , mathematical analysis , materials science , mathematics , metallurgy , physics , microbiology and biotechnology , quantum mechanics , biology
We describe here the synthesis of two[ 11 C‐methyl]labelled analogs of choline and the influence of the solvent, addition of a base, and reaction time on the radiochemical yield. The reactions produced equally good yields in methanol and acetonitrile and reached maximum radiochemical yield at about 5‐10 min. The addition of a base in the case of [ 11 C‐methyl]pyrrolidinocholine increases the radiochemical yield. Optimum radiochemical yields were 30% for[ 11 C‐methyl]piperidinocholine and 40% for[ 11 C‐methyl]pyrrolidinocholine for two choline analogs.