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Synthesis of stable isotope enriched metabolites of theophylline
Author(s) -
Matjeka Edward R.,
Banks Richard C.,
Mercer Gary D.,
Musser Beth,
Vestal Robert E.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230909
Subject(s) - chemistry , theophylline , xanthine , stable isotope ratio , isotope , stereochemistry , organic chemistry , enzyme , medicine , physics , quantum mechanics , endocrinology
Four isotopically labelled metabolites of theophylline were synthesized. The syntheses of 1‐(methyl‐d 3 luric‐2,8‐ 13 C 2 ‐acid; 1,3‐di( methyl‐d 3 )uric‐2,8‐ 13 C 2 ad d; 3‐(methyl‐d 3 lxanthi ne‐2‐ 13 C. 7‐ 15 N and 1‐ (methyl‐d 3 )xanthine‐2‐ 13 C are described. Modifications in published procedures for the synthesis of the corresponding unlabelled compounds were required to achieve the micro scale necessary to accommodate the small starting quantities of expensive stable isotope labelled precursors.