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A facile synthesis of 4′‐[ 2 H]‐uridine and its derivatives
Author(s) -
Ajmera Sudhir,
Massof Steven,
Kozarich John W.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230908
Subject(s) - chemistry , uridine , pyrimidine , tritium , hydrogen peroxide , deuterium , combinatorial chemistry , radiochemistry , stereochemistry , organic chemistry , rna , biochemistry , quantum mechanics , physics , nuclear physics , gene
A facile method for the introduction of deuterium at the C 4 , position of uridine and its derivatives involves the reaction of appropriately protected 4′,5′‐unsaturated pyrimidine nucleosides with B 2 D 6 , followed by hydrogen peroxide oxidation under alkaline conditions. The method described herein is also adaptable to the introduction of tritium at C 4 , position of pyrimidine nucleosides for use in mechanistic studies of DNA‐degrading drugs.