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Synthesis of [ 14 C]alaproclate
Author(s) -
Gawell Lars
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230905
Subject(s) - chemistry , ketone , acetone , yield (engineering) , grignard reagent , reagent , alcohol , grignard reaction , chloride , carbon 14 , organic chemistry , materials science , physics , quantum mechanics , metallurgy
The synthesis of carbon‐14 labelled alaproclate from [2‐ 14 C]acetone in three steps is described. The label is introduced by the reaction of a benzylic Grignard reagent with the ketone yielding a tertiary alcohol Subsequent esterification with an α‐bromocarboxylic acid chloride and a.ination furnished the title compound in a 13% overall radiochemical yield.