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Synthesis of tritium labelled (−)‐3‐PPP, a selective dopamine autoreceptor agonist
Author(s) -
Thorberg SethOlov,
Johansson Lars,
Gawell Lars,
Sahlberg Christer
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230903
Subject(s) - chemistry , tritium , autoreceptor , piperidine , tritium illumination , agonist , nuclear magnetic resonance spectroscopy , radiochemistry , nuclear chemistry , stereochemistry , receptor , biochemistry , physics , nuclear physics
3 H‐(‐)‐3‐PPP ( 11 , (S)‐3‐(3‐Hydroxyphenyl)‐N‐propyl‐[3,4‐3H]piperidine) was prepared by hydrogenation of compound 3 , with tritium gas followed by resolution of the racemic mixture. The incorporation of tritium was verified by tritium NMR spectroscopy. Also described is the synthesis and NMR interpretation of two isomeric unsaturated tetrahydropyridine derivatives i.e. compounds 8 and 10 .