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Synthesis of 14 C‐bucromarone succinate and hydrochloride
Author(s) -
Nicolas Colette,
Verny Michel,
Maurizis JeanClaude,
Payard Marc,
Faurie Michel
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230806
Subject(s) - chemistry , hydrochloride , oxalic acid , labelling , specific activity , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , enzyme
Abstract 14 C‐Bucromarone, 2‐[4‐(3‐N,N dibutylamino propoxy) 3,5‐dimethyl benzoyl] chromone, was synthesized from (U‐ 14 C) oxalic acid. The labelling takes place at the first step of the synthesis, and allowed the obtention of −14 C‐Bucromarone succinate, with a specific activity of 7.45 mCi/mmol, i.e. 275.6 MBq/mmol; −14 C‐Bucromarone hydrochloride, with a specific activity of 7.5 mCi/mmol, i.e. 277.5 MBq/mmol.