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Synthesis and biodistribution of radioiodinated selenonium salts: Potential myocardial imaging agents
Author(s) -
Parikh A. S.,
Basmadjian G. P.,
Gilliland D. L.,
Greenwood R. B.,
Rieger J. A.,
Weaver A.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230804
Subject(s) - chemistry , biodistribution , tetrafluoroborate , selenide , iodide , yield (engineering) , nuclear chemistry , medicinal chemistry , radiochemistry , iodine , sodium iodide , chemical synthesis , inorganic chemistry , organic chemistry , catalysis , biochemistry , in vitro , ionic liquid , materials science , selenium , metallurgy
( o ‐[ 125 I]iodobenzyl)benzylmethylselenonium tetrafluoroborate ( 1 ) and ( o ‐[ 125 I]iodobenzyl)dibenzylselenonium tetrafluoroborate ( 2 ) were synthesized by methylation and benzylation of o ‐[ 125 I]iodobenzyl benzyl selenide respectively. The starting compound o ‐iodobenzyl benzyl selenide was radioiodinated with sodium [ 125 I]iodide by melt‐exchange in a sealed ampoule maintained at 75°C for 12 hours, with subsequent chromatographic purification yielding the pure compound in a radiochemical yield of 33.0% and specific activity of at least 68.0 mCi/mmol. Tissue distribution studies of compounds 1 and 2 , performed in rats, showed that the labelled compounds accumulated rapidly in the heart. The maximum heart‐to‐blood ratios for compounds 1 and 2 were 4.2:1 and 4.4:1 compared to that of 2.0:1 for previously synthesized [ 75 Se]Trimethylselenonium Iodide ( 3 ).