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Synthesis of [ 3 H]zolpidem
Author(s) -
Allen John,
Parent Ginette,
Tizot André
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230803
Subject(s) - zolpidem , chemistry , radioligand , hypnotic , pyridine , tritium , stereochemistry , pharmacology , medicinal chemistry , receptor , biochemistry , medicine , physics , nuclear physics , insomnia
Zolpidem is a novel hypnotic agent possessing a substituted imidazo[1,2‐ a ] pyridine structure. The synthesis of the tritium labelled compound with a specific activity of 60.5 Ci/mmol is described. This new radioligand was initially used to establish and characterize the binding properties of Zolpidem in the rat brain.