Premium
Synthesis of 1‐hydroxy‐3‐[3‐ 3 H‐(4‐chlorophenyl)‐2‐piperidone. Labelling of a new antiinflammatory hydroxamic acid
Author(s) -
Bovy P. H.,
Callaeri M.,
Gillet C.,
De Decker J. M.,
Winand M.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230603
Subject(s) - chemistry , labelling , tritium , iodine , benzene , hydroxamic acid , ring (chemistry) , chlorine , chlorine atom , catalysis , tritium illumination , medicinal chemistry , radiochemistry , combinatorial chemistry , organic chemistry , biochemistry , physics , nuclear physics
Compound 1 , synthezized as a potential topical antiinflammatory agent, has been labelled with tritium on the benzene ring in a position neighboring a chlorine atom. An iodinated precursor was prepared by an original six‐step synthesis. Selective catalytic iodine‐tritium replacement was achieved under mild reaction conditions.