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Synthesis of 4‐(3‐t‐butylamino‐2‐hydroxypropoxy)‐benzimidazol‐2( 11 c)‐one (cgp 12177)
Author(s) -
Boullais C,
Crouzel C,
Syrota A
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230514
Subject(s) - chemistry , phosgene , positron emission tomography , benzene , radiochemistry , specific activity , reagent , medicinal chemistry , stereochemistry , organic chemistry , psychology , neuroscience , enzyme
4‐(3‐t‐butylamino‐2‐hydroxypropoxy)‐benzimidazol‐2 ( 11 C)‐one (CGP 12177) was synthetized in a short time (30 min) and with a specific activity of 130 mCi/μMol for β receptor studies by the positron emission tomography. The radioactive reagent was 11 C‐phosgene and the starting material 1‐(3‐t‐butylamino‐2‐hydroxypropoxy)‐2.3‐diamino benzene.

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