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Syntbesis of 14 C‐labeeed felbamate from phenylacetic‐(methylene‐ 14 C) acid
Author(s) -
Choi Yong M.,
Kucharczyk Norbert,
Sofia R. Duane
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230512
Subject(s) - phenylacetic acid , felbamate , chemistry , methylene , yield (engineering) , carbon 14 , stereochemistry , organic chemistry , nuclear chemistry , nuclear physics , materials science , neuroscience , metallurgy , epilepsy , biology , carbamazepine , physics
A synthetic procedure for the preparation of 2‐phenyl‐1,3‐propanediol‐2‐ 14 C dicarbamate. starting with phenylacetic‐(methylene‐ 14 C) acid was developed. The procedure from phenylacetic acid to 2‐phenyl‐1,3‐propanediol dicarbamate has four steps via phenylmalonic acid and 2‐phenyl‐1,3‐propanediol. The overall yield of all four steps was 28%.