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Synthesis and purification of 14 C N‐2‐hydroxyethyl‐N‐nitrosourea
Author(s) -
Perez G.,
Possagno E.,
Caponecchi G.,
Lilla E.,
Polcaro C.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230414
Subject(s) - chemistry , yield (engineering) , elution , nitrosourea , ether , high performance liquid chromatography , chromatography , diol , ethanolamine , column chromatography , sequence (biology) , nuclear chemistry , organic chemistry , biochemistry , medicine , materials science , surgery , chemotherapy , metallurgy
14 C N‐2‐hydroxyethyl‐N‐nitrosourea was prepared at a specific activity of 30 mCi/mmol and 1.29 mCi/mmol by a two‐step synthetic sequence using 14 C ethanolamine as the labelled precursor. Its purification was performed by HPLC using a Lichrosorb‐DIOL column eluted by ethyl ether. The overall radiochemical yield was 10%.