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Preparation of [ 2 H]‐paraformaldehyde
Author(s) -
Ouzounian Joseph G.,
Anet Frank A. L.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230408
Subject(s) - bromoform , paraformaldehyde , chemistry , formaldehyde , molecule , organic chemistry , aldehyde , catalysis , chloroform
Polymeric [ 2 H]‐formaldehyde, which is useful for the synthesis of a variety of labelled molecules, is prepared from bromoform in four steps. The isotopic purity of the final product depends on that of the [ 2 H]‐bromoform made in the first step, and is measured after conversion of the [ 2 H] formaldehyde to [2‐ 2 H]‐5,5‐dimethyl‐1,3‐dioxane.