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Synthesis of seven deuteromethyl‐caffeine analogues observation of deuterium isotope effects on cmr analysis
Author(s) -
Falconnet J. B.,
Brazier J. L.,
Desage M.
Publication year - 1986
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580230305
Subject(s) - chemistry , isotopomers , deuterium , kinetic isotope effect , isotope , carbon 13 nmr , deuterium nmr , xanthine , caffeine , molecule , iodide , radiochemistry , stereochemistry , organic chemistry , nuclear physics , medicine , enzyme , endocrinology , physics
This article describes synthesis of all 7 N‐trideuteromethyl isotopomers of caffeine by reaction of trideuteromethyl iodide (C 2 H 3 I) with the appropriate xanthine molecules. The use of proton. deuterium and carbon‐13‐NMR as a first step in purity assessment revealed 13 C‐NMR deuterium isotope effects on the resonance of perdeuteromethyl carbons.