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Synthesis of [ 14 C]methylphosphonic difluoride
Author(s) -
Bechtold W. E.,
Dahl A. R.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221112
Subject(s) - chemistry , difluoride , yield (engineering) , dimethyl methylphosphonate , methyl iodide , iodide , radiochemistry , organic chemistry , nuclear chemistry , metallurgy , materials science
The synthesis of [ 14 C] methylphosphonic difluoride is described. First, [ 14 C]methyl iodide was used to catalyse the conversion of trimethyl phosphite to dimethyl [ 14 C]methylphosphonate by the Arbusov reaction. The dimethyl methylphosphonate was then chlorinated with PCl 5 and fluorinated with SbF 3 . Radiochemical yield from the reaction was 25%.