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Radioiodinations of organic molecules on silica gel surfaces
Author(s) -
Boothe Thomas E.,
Finn Ronald D.,
Vora Manhar M.,
Emran Ali,
Kothari Paresh J.,
Kabalka George W.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221103
Subject(s) - chemistry , phenols , yield (engineering) , silica gel , aryl , solvent , molecule , organic chemistry , chromatography , alkyl , materials science , metallurgy
To investigate radioiodinations on chromatographic surfaces, 131 I − has been allowed to react with various organic compounds on silica gel chromatography plates. Antipyrine, which reacts with 131 I − to give 4‐[ 131 I]iodoantipyrine, was used as a model compound. The yield varied as a function of the initial solvent used; hydrogen ion concentration; contact time on the surface; and temperature. These results were extended to other reactive compounds such as substituted 3H‐pyrazol‐3‐ones; substituted phenols, including L‐tyrosine; substituted anilines; 5‐iodouracil; some secondary alkyliodides and alkylbromides; alkylboranes; and aryl‐and vinylboronic acids.