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Synthesis of hexadeuterated hexestrol (R, S)‐3,4‐di‐(4‐hydroxyphenyl)hexane‐1,1,1,6,6,6‐ 2 H 6
Author(s) -
de Clercq P. J.,
Hoflack J. M.,
van Royen L. A.,
van Peteghem C. H.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221012
Subject(s) - hexestrol , chemistry , hexane , stereochemistry , medicinal chemistry , organic chemistry , diethylstilbestrol , biochemistry , hormone
A short and stereoselective synthesis of hexadeuterated hexestrol is described, involving catalytic hydrogenation of Z‐3,4‐di‐(4‐methoxyphenyl)hex‐3‐ene‐1,1,1,6,6,6‐ 2 H 6 followed by demethylation using sodium thioethoxide in dimethyl formamide.