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Preparation of ring‐tritiated and of aldehyde‐ 14 C‐labelled 1‐pyrenecarboxaldehyde
Author(s) -
Posner Gary H.,
Barness Itzhak,
Biggley William H.,
Seliger Howard H.,
Kaplan David C.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580221005
Subject(s) - chemistry , pyrene , aldehyde , tritiated water , ring (chemistry) , halogenation , tritium , chemical synthesis , radiochemistry , organic chemistry , catalysis , biochemistry , in vitro , physics , nuclear physics
A short, direct, and efficient synthesis of very high specific‐activity ring‐tritiated 1‐pyrenecarboxaldehyde is described. A novel aspect of this synthesis involves direct bromination of an aromatic pyrene system carrying an electronwithdrawing aldehyde group. Synthesis of 14 C‐labelled 1‐pyrene‐carboxaldehyde is also described. Each of these compounds was converted in one step into the correspondingly radiolabelled trans‐1‐(2′‐methoxyvinyl) pyrene.