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Synthesis of specifically‐labelled tritiated benzimidazole carbamates
Author(s) -
Lacey E.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220904
Subject(s) - benzimidazole , chemistry , halogenation , bromine , acetic acid , radiochemistry , organic chemistry
Benzimidazole carbamates are thought to exert their biological activity as anthelmintics by binding to helminth tubulin. To investigate this hypothesis, the synthesis of two specifically‐labeled tritiated benzimidazoles, parbendazole and oxibendazole, has been accomplished. These labels were prepared by debromination of the appropriate 5‐bromo analogue using sodium borotritide in the presence of palladium chloride. The brominated derivatives were synthesized by the bromination of the benzimidazole using bromine in glacial acetic acid.